The mayor’s renewed push on Wednesday to rezone SoHo to increase affordable housing has the support of major real estate and development groups, but even they acknowledge overcoming community opposition will be a significant hurdle.

“All of the mayor’s rezoning efforts have been met with furious political and legal challenges,” said Jessica Katz, executive director of the Citizens Housing and Planning Council, “so we’re just happy that the mayor’s office is giving SoHo at least a fair shake and is going to defend it on the merits.”

Mayor Bill de Blasio announced on Wednesday that the rezoning effort for SoHo and NoHo would move forward into the city’s public land-use review process. It would encompass the area bound by Canal Street to the south, Houston Street and Astor Place to the north, Lafayette Street and the Bowery to the east, and Sixth Avenue and West Broadway to the west.

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